Animal Care & Use Program Newsletter
A newsletter brought to you by Animal Care Services on behalf of Dr. Helen M. Burt, Associate Vice-President Research & Innovation to faculty, staff, students, and community members in the UBC Animal Care & Use Program.
In this issue:
- CCAC: Update for UBC Assessment Visit | New Guidelines for Rats and Mice
- UBC Veterinarians: Update on University Veterinarian
- In Memory of Dr. Susanne M. Clee
- ACC: Research Review in the Time of COVID-19 | New SOPs Approved
- ACUP Procurement: Ordering Animals and AVP Supplies in Mosaic
- Mosaic Enhancement Project
- Post Approval Monitoring
- Animal Care Services Training: Resumption of In-Person Training
- ACUP Facilities Updates
- Strategic Plan Update
- ACUP SharePoint
The CCAC conducted a full assessment visit with UBC during March 5-8, 2019 and the CCAC sent us their report in August 2019. We had 8 commendations, 3 serious, and 8 regular recommendations. Responses to all recommendations were submitted to the CCAC by February 2020. A final update from UBC is due in September prior to a decision by the CCAC Assessment and Certification Committee. Thank you to all who have contributed to a strong animal ethics and care program at the University of British Columbia and affiliates.
The CCAC has released the CCAC Revised Guidance on Euthanasia Using Carbon Dioxide (2020). The revised guidance was developed by the CCAC Secretariat staff taking into consideration the most recent scientific literature and expert opinion, and was reviewed by the CCAC Standards Committee and CCAC Board of Directors. It replaces the guidance concerning carbon dioxide use in the CCAC guidelines on: euthanasia of animals used in science (2010), specifically, Guideline 13.
The CCAC updated their guidelines for both mice and rats. These documents, along with their associated FAQs, address conditions normally present in laboratories housing mice and rats, and provide a framework for the implementation of evidence-based practices, with the aim of improving the welfare of mice and rats.
Our clinical veterinarians can assist you with animal care protocol development and pre-review, model development, and animal welfare.
For more information, please visit our SharePoint site or contact our team:
|Dr. Cathy Schuppli, Interim University Veterinarian & Clinical Veterinarianfirstname.lastname@example.org||ARU|
|Dr. Shelly McErlane, Senior Clinical Veterinarian and Head of Trainingemail@example.com||BRC, CDM, ICORD, JBRC, UBCO|
|Dr. Brittany Imlach, Clinical Veterinarianfirstname.lastname@example.org||CCM|
|Dr. Davis Wood, Clinical Veterinarianemail@example.com||BCCRC, BCCHR, CMMT, Forestry, HLI, InSEAs, LSI, MBF, MOF, Zoology|
|Dr. Laura Mowbray, Clinical Veterinarianfirstname.lastname@example.org||CCM, UBC Dairy Education and Research Centre, UBC Farm|
|Dr. Po-Yan Chengemail@example.com||On leave until fall 2020|
|Evenings and weekends||604-822-9000||-||-|
Update on University Veterinarian
Dr. Ian Welch will return as Director, Veterinary Services & Research Support, and University Veterinarian at UBC in August 2020. He received his DVM from the University of Guelph in 1992 and completed a Certificate in Veterinary Forensic Science and Medicine in 2019. Dr. Welch has nearly 40 years of experience in clinical research pathology and forensic settings.
We were saddened to hear of the tragic and sudden passing of Dr. Susie Clee. Susie was a valued member of the UBC Animal Care Committee, where she chaired our post-approval monitoring subcommittee for several years. Her thoughtful contributions, attention to detail, and big heart will be sorely missed.
To learn more about Susie’s many accomplishments and her wishes for donations, please visit In Memory of Dr. Susanne Michelle Clee.
The UBC Animal Care Committee, responsible for the oversight of animal research, returned to full function in May 2020. This includes:
Reviewing all submitted protocols/amendments/renewals
Conducting protocol review meetings via videoconference
Expediting the review of all COVID-19 related protocols
Conducting facility site visits via videoconference with managers
Post-approval monitoring (PAM) team providing oversight of animal use
The ACC is pleased to announce the following new SOPs, recently approved in June 2020:
These SOPs can also be found in Standard Operating Procedures.
If you have any questions about these SOPs, please contact Suzanne Richardson, Manager, UBC Animal Care, Biosafety & Radiation Committees.
The ACC is Seeking New Community Members!
Community representatives are selected to represent the general community and have no formal connection with the Institution. Community representatives are particularly important to the function of the ACC as they represent the wider community and help to provide public accountability for the Committee and its decisions.
If you know anyone not affiliated with the university who may be interested, please contact Suzanne Richardson for more information.
Phased Resumption of Research Activities
In response to COVID-19, the following services are limited to exempted research users:
All animal transfers between facilities
Transportation of animals
Ordering of any new animals
For more information, please visit the Office of the Vice-President Research + Innovation.
AVP orders are placed twice a week. Please submit any order requests by Monday/Wednesday 11 a.m. to ensure they are included in that day's order. Any urgently required pharmaceuticals/supplies continue to be ordered ASAP.
For any questions or concerns regarding animal orders, transfers, procedures, and technical work, please contact Janice Kang at firstname.lastname@example.org or 604-827-4938.
Ordering Animals and AVP Supplies in Mosaic
All animal and supply ordering requests are available through Mosaic. As an alternative to submitting order forms to email@example.com, order requests through Mosaic will allow for faster and more transparent processing.
See here for a 2-minute video tutorial: How-to Animal Ordering with Mosaic.
The PI and their authorized speedchart users as communicated to UBC ACUP Procurement (firstname.lastname@example.org) are able to request orders through Mosaic.
Associated Veterinary Purchasing (AVP) Catalog
The AVP catalog is uploaded into Mosaic so researchers can request any products available via AVP directly in Mosaic.
As reference, researchers can also view the AVP catalog by visiting avpbc.com before submitting order requests to Animal Care Services. Please use the following credentials to view the AVP catalog:
Customer Number: 228628
Username: ACS Users
AVP is a veterinarian-owned buying group and distributor of pharmaceuticals. AVP sells only to licensed veterinarian healthcare professionals of British Columbia. Researchers are encouraged to login to the AVP catalog to view pricing and product availability only. Orders for AVP products must still be placed to the UBC ACUP Procurement team.
As a courtesy, if you are aware of any construction activities at or around your facility that may impact deliveries, please contact email@example.com with details so we can ensure animals are delivered in a timely manner.
In alignment with VPRI’s goal of making research services more accessible and transparent, Animal Care Services has committed to building one integrated animal management platform across the UBC Animal Care and Use Program for the ordering, housing, breeding, managing and billing of animals.
We are excited to announce that the Mosaic Enhancement Project team has successfully completed the following deliverables to date:
CWL integration to enable single sign-on for user
RISe integration to ensure compliance with animal protocols
Animal and AVP ordering through Mosaic for a more transparent web-based process. Rather than submitting animal and AVP order forms as a Word document to “ANCA Orders” via email, order requests can be filled and submitted within Mosaic.
Census and per diem charging in Mosaic for one integrated billing process for Animal Care Services, and rolled out to other ACUP facilities as requested.
Invoicing via Mosaic
The project team is working with the ACUP facilities on enhanced billing and reporting functionality so researchers have increased transparency on animal related costs.
For progress updates, frequently asked questions, and other information visit our Mosaic Enhancement Project SharePoint site.
For questions about the Mosaic Enhancement Project please contact Barbara Sommer, Manager, Strategic Initiatives or your Facility Mosaic Administrator.
The UBC Post-Approval Monitoring team works closely with the Animal Care Committee. Post-approval monitoring can facilitate ongoing protocol assessment and regulatory compliance by monitoring protocols after the ACC’s initial protocol approval. The team consists of the PAM Veterinarian, Dr. Madeleine Stephens and PAM Compliance Officer, Kathy Banks.
During the Stage 1 of research curtailment, in-person PAM facility audits by Kathy Banks and PI-specific procedural audits by Dr. Madeleine Stephens were suspended. The PAM program has been remotely overseeing compliance by relying on regular communications with facility managers and animal care staff, and direct communication with PIs who obtained exemptions to continue their research. This has allowed the PAM team to provide oversight where needed and as required. A plan is being developed for resuming facility audits during Stage 2 resumption and for procedural audits during Stage 3 resumption. If you have any PAM related questions or concerns, reach out to the PAM Team.
Maintaining a comprehensive training and education program is essential to our ongoing commitment to high-quality science and promoting optimal welfare in our Animal Care and Use Program. Under the leadership of Senior University Veterinarian Dr. Shelly McErlane, the ACS Training team provides an ACUP-wide Animal Care Training program.
Resumption of In-Person Training Courses
The ACS Training team resumed in-person training courses the week of July 6, 2020 in a limited capacity.
During Stage 1 of UBC Animal Care Services (ACS) research resumption, priority for webinar and classroom training will be given to those with Animal Research Resumption Access Request Approvals. For groups with resumption approval, visit ACS Online & Lab Rodent Courses to learn more and enroll. Please read the course materials and complete the course scheduling survey so we may follow up with webinar and hands-on training details.
The ACS Training team is taking these precautionary measures:
Live webinars to replace in-person hands-on sessions where possible
Limited capacity for in-person hands-on sessions
Clear acrylic barriers in the training area
Additional disinfecting practices
Mandatory personal protective equipment (PPE), provided to trainees at no cost. PPE includes a face shield, a surgical mask, a lab coat, and gloves.
Requirement for all trainees to maintain proper hygiene and physical distancing.
If you are scheduled for in-person sessions, you must:
Read all emails from ACS Training regarding safety protocols upon arrival
Assess yourself for any common symptoms of COVID-19, immediately prior to coming on campus. If you experience symptoms of COVID-19, you should:
Remain off campus and self-isolate at home for a minimum of 10 days
Contact your health care provider or use the BC COVID-19 Self-Assessment Tool
Contact the ACS Training team to reschedule – you will not be charged any cancellation fees
Updated online training materials are now hosted on a new UBC learning management platform, the Workplace Learning Ecosystem (WPL). This change makes it easier for trainees to register, pay for, and track their learning.
Feedback from Participants on Webinar Courses
Some comments from students who completed our webinar courses in July 2020.
- “It was very interesting and informative, especially the clinical assessment and monitoring portions.”
- “A well designed and taught course, never felt it was different from doing it in class!”
- “Really well planned. Covered in depth topic. Really worth for 4 hours.”
Animal Care Services
Animal Care Services works closely with the Animal Care Committee to provide services in support of the UBC Animal Care & Use Program.
ACS Diagnostic & Research Histology Laboratory pricing was refreshed on July 1, 2020 to include a few new available services. The goal of the ACS Lab is to provide accurate, timely, and cost effective diagnostic services to researchers. We value our customers and strive to keep costs reasonable while maintaining our high quality services. Any fee increases reflect similar increases in our analytical costs. Fees generally reflect the expertise and laboratory supplies required to perform the tests. Referral or outsourced testing is dependent upon the referral lab’s testing fees and are adjusted annually per the provider’s pricing.
Centre for Comparative Medicine (CCM)
CCM is a 50,000 sq. ft. animal facility capable of holding non-human primates, sheep, and swine. The CCM facility includes Containment Level 2, procedural and surgical space, diagnostic laboratory, and training surgical stations.
For more detailed information or to initiate a project budget, please contact Brian Ryomoto, Project Coordinator.
CCM is preparing for Stage 2 Research Resumption where expanded on-campus research activities may only be conducted under an approved Animal Research Resumption Access Request.
The facility is undergoing expansion to add a 9.6T MRI to the building’s north side. This addition will allow us to expand our capacity to perform innovative research in human and animal health. The estimated project completion date is March 2021.
Center for Disease Modeling (CDM)
CDM is a 90,000 sq. ft. animal facility capable of holding 27,000 rodent cages. CDM is a main barrier facility and operations include barrier, breeding, procedural, and surgical space.
CDM supervisors and management can be contacted at firstname.lastname@example.org.
Access to CDM is currently restricted to specific individuals with Animal Research Resumption Access Request Approvals to maintain essential research.
TEF4 Building Construction
The construction of Technology Enterprise Facility 4 (TEF4), a proposed 13-storey office/lab building at the corner of Agronomy Rd and Health Sciences Mall, has been temporarily paused during this time.
New User Facility Orientations
In March, CDM facility orientations for new users were suspended during the research curtailment period. Facility orientations resumed on a limited basis during the week of July 13.
Modified Barrier Facility (MBF)
The Modified Barrier Facility is a 22,000 square-foot rodent in vivo, multi-barrier facility equipped with multiple zones, including conventional and barrier zones, a CL2 area, as well as procedures space. The facility is equipped with 15 animal holding rooms and 18 procedure rooms and laboratories.
Access to MBF is currently restricted to specific individuals with Animal Research Resumption Access Request Approvals to maintain essential research.
MBF supervisors and management can be contacted at email@example.com and 604-827-1506.
New User Facility Orientations
In March, MBF facility orientations for new users were suspended during the research curtailment period. Facility orientations resumed in a limited basis during the week of July 13.
Facility for Infectious Disease and Epidemic Research (FINDER)
The Facility for Infectious Disease and Epidemic Research is a 6,700 square-foot Containment Level 3/Biosafety Level 3 (CL3/BSL3) facility located in the Life Sciences Centre. The facility is dedicated for discovery research in the field of infectious diseases caused by risk group 3 (RG3) pathogens such as highly pathogenic influenza A viruses, West Nile virus, and Mycobacterium tuberculosis. FINDER has seven self-contained customized laboratories, including an Analytical/Proteomics lab, Live Imaging labs, and several microbiological labs with dedicated animal holding rooms for small rodents and ferrets:
- Housing for up to 128 mouse cages (640 mice) per room.
- Individual ventilated caging systems to ensure biosafety and avoid cross contamination.
For more information, contact Dean Airey, Lab Manager, FINDER.
Biosciences/Medicine In Vivo Facility, UBC Okanagan Campus
The Biosciences/Medicine In Vivo Facility (IVF) at the UBC Okanagan campus began operations in 2016 and currently houses several hundred rodents. For more information, contact Naomi Winckler, Facility Supervisor.
Centre for Molecular Medicine and Therapeutics (CMMT)
The UBC Transgenic Animal Facility located at the Centre for Molecular Medicine & Therapeutics is a high barrier specific pathogen free mouse facility. Located on the Children & Women’s hospital site, the facility has over 17,000 square-feet of space and a 7,000 cage capacity in order to facilitate research projects with both academia and industry.
The facility consists of eight animal holding rooms, eight procedure rooms, behavior suite with four testing rooms and a reverse light-cycle holding room, dedicated surgical suite, molecular biology lab, and cell culture suite. The CMMT Transgenic Animal Facility has a large cage wash area with dedicated staff, is home to an advanced receiving/quarantine facility with multiple glovebox isolators, and a mouse ultrasound suite. In addition, the facility has a transgenic mouse production and cryopreservation suite which is home to the Mouse Animal Production Service (MAPS).
Animals are housed in individually ventilated cages with automatic water. If you do not have dedicated animal staff, our core facility staff can accommodate most of your research needs. Incoming animals are accepted from all major vendors, following a short quarantine period.
We currently have surplus capacity. If you are interested, or would like more information, please email firstname.lastname@example.org.
Mouse Animal Production Service (MAPS)
The primary role of the Mouse Animal Production Service (MAPS) is to support investigators in producing and using genetically modified mouse models.
In graduate student Zeinab Mirjalili Mohanna’s latest publication, MAPS helped create a novel mouse model of aniridia using CRISPR gene-editing technologies!
Currently there is a lack of effective treatments for aniridia, a rare congenital eye disorder that leads to blindness. The small eye (Sey) mouse is a widely-accepted model for aniridia. With the help of MAPS, Zeinab Mirjalili Mohanna created a novel mouse strain (Fey) by adding a 3xFLAG tag onto the Sey allele, allowing for the differential detection of WT and CRISPR-corrected proteins.
To confirm the sole causality of the Sey mutation in this mouse, MAPS microinjected an optimized in vitro CRISPR strategy into the novel mouse embryos, leading to a successful germline correction of the mutant eye phenotype in newborn pups!
Moving forward, this novel mouse and CRISPR strategy will be used to work towards a somatic CRISPR therapy for aniridia!
For more information about services from MAPS please contact us at email@example.com.
BC Cancer Research Institute, Animal Resource Centre (BCCRI, ARC)
We hope our colleagues and friends are well, and successfully navigating the changes due to the COVID-19 pandemic, since the last newsletter! Looking forward to connecting, soon!
We are pleased to announce that the research program at BC Cancer, a part of the Provincial Health Services Authority (PHSA), has become a formal UBC-approved research institute, resulting in a name change to: BC Cancer Research Institute.
The Animal Resource Centre is a 20,000 sq ft barrier, with 18 animal holding rooms, and 9 procedure rooms. It continues to promote its imaging equipment including PET/CT, SPECT/CT, Maestro, and SARRP, as well as a Biopticon tumour imager (biopticon.com). We are looking forward to installing a new IVIS, shortly.
The ARC has ramped up the breeding colony production, since the research curtailment, so the mouse strains below will soon be available for purchase, and are transferable across UBC animal facilities. Demand is increasing, so don’t delay ordering for your resumed studies.
The facility is a 20,000 ft space with 18 animal holding rooms, and 9 procedure rooms. It continues to promote its Imaging equipment including PET/CT, SPECT/CT, MRI, Maestro, and SARRP, as well as a Biopticon tumour imager.
As usual, the ARC produces several mouse strains for purchase (below), which are transferable across UBC animal facilities. Demand is increasing, so don’t delay ordering for your upcoming studies.
Nod Scid (NOD.CB17- Prkdcscid/J),
Nod Scid IL2KO (aka NOD Scid gamma),
NRG (NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ),
NRG-3GS (NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J),
Pep 3B (B6.SJL-Ptprca Pep3b/BoyJ)
The BCCRI Transgenic Core’s Genetic Modelling Centre continues to provide services for the research community in British Columbia, including the generation and utilization of genetically engineered mouse models. Services include mouse strain cryopreservation and rederivation, standard and CRISPR/Cas9-mediated ESC genomic modification, microinjection of targeted ESC, pronuclear/cytoplasmic microinjections into zygotes using standard and CRISPR-Cas9 mediated editing, embryonic stem (ES) cell derivation, and in vitro fertilization. The ARC’s satellite Modified Animal Resource Centre (MARC, within the BCCRI), facilitates the importation of approved strains that don’t meet UBC’s exclusion list criteria, allowing models to be rederived into the ARC’s Barrier. Mice can then be shipped to other animal facilities, including CDM.
The Investigational Drug Program offers services to support toxicology and pharmacology (PK, Biodistribution, Efficacy) studies and is certified by Standards Council Canada to conduct GLP studies. These, and all studies conducted in the ARC, are with oversight by the UBC Animal Care and Use Program.
For more information, please contact us at:
General, Access, and Training Inquiries: Gayle Paquette
Ordering and Mosaic Inquiries: Jennifer Yeung
Centre for Genetic Modelling: Nicole Hofs
IDP or GLP Inquiries: Nancy Dos Santos
Centre for Heart Lung Innovation (HLI)
The Genetically Engineered Models Facility at the HLI has space available for your rodent studies. With technical expertise in heart and lung models we can work with you to realize your research goals. HLI also offers a range of lab services available to all researchers internal and external to the university.
Our core managers can offer expert technical assistance in Histology, Flow Cytometry, Nanostring, PCR, Micro-CT, Imaging, Biobanking and Information Technology We recently acquired a new Super-resolution microscope and Coherent laser and will be upgrading our digital slide scanning capabilities with a new 400 slide capacity scanner. Contact Claire Smits and 604-806 8852.
In addition to the work we completed over the previous three years, we are pleased to report that a significant amount of work, in support of the strategic plan, has taken place since our last ACUP newsletter.
|People Goal||Investment Goal||Ethics Goal||Outreach Goal|
Work in Progress:
Work in Progress:
Work in Progress:
Work in Progress:
Please direct comments to Michelle Tan, Associate Director, Operations, Animal Care Services.
The ACUP SharePoint provides information about all relevant services related to animal use at UBC, e.g. veterinarian contact details, SOPs, safety, facility information.
Access to the ACUP SharePoint site is automatically granted to all researchers with an Animal Care Committee approved protocol, ACUP facility managers, Animal Care Services staff, the Animal Care Committee, and the In Vivo Research Facilitation Committee.
To access the site, use the following link: animalcare.share.ubc.ca.
Please contact ACS News if you do not currently have access or if you encounter any issues accessing the page.
|Animal Care & Use Program||Questions or comments?|
Michelle Tan, Associate Director, Operations, Animal Care Services
Suzanne Richardson, Manager, UBC Animal Care, Biosafety & Radiation Committees